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IC50 values are generated from 10-point dose-response curves.
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Responses may be more likely in certain patient subgroups and may be especially pronounced in patients with an EGFR mutation (this may be the main or only reason we have identified EGFR inhibitors as a preferred treatment for BAC).
Combined and Multi-Modal Therapy.
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In the last trial, PFS, but not OS, was longer with gefitinib versus pemetrexed, and serious adverse events more frequent with gefitinib.
In eukaryotes, if the alteration affects gametic cells the change is a genetic mutation and can be inherited; if body cells (nonsexual) are affected the mutation is called somatic mutation and will not normally be inherited.
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The lack of significant adverse reactions in most of our treated patients is also consistent with a lower trough concentration of erlotinib when this drug is given at 25 mg instead of 150 mg.
Non-small cell lung cancer treated with Erlotinib: heterogeneity of 18F FDG uptake at PET- association with treatment response and prognosis.
Phase II study of capecitabine and oxaliplatin in first- and second-line treatment of advanced or metastatic colorectal cancer.
Bronchioloalveolar carcinoma, or BAC, is a unique subtype of non-small cell lung cancer ( NSCLC) that has unique features in terms of the demographics of who gets it, how it appears on scans, how it often behaves, and potentially in how it responds to treatment.
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