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Because CYP3A4 is known to have homotropic and heterotropic substrate interactions, the docking with ixabepilone suggested that with this compound, such interactions are not likely to occur because the substrates are large enough to occupy the major part of the active site (volume of epothilone B has been estimated to be 709 Å 3).
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The clinical study with ketoconazole and ixabepilone clearly indicate that inhibition of CYP3A4 by ketoconazole significantly increases the exposure of ixabepilone in the blood and alters drug-target effects.
Rare cases of serious cardiovascular adverse events, including death, ventricular tachycardia and tordades de pointes have been observed in patients taking ketoconazole tablets concomitantly with terfenadine, due to increased terfenadine concentrations induced by ketoconazole tablets.
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For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
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Tell your physician if you are pregnant or plan to become pregnant during this steroid treatment.
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