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To these purposes, presymptomatic (2-3 months of age) and symptomatic (12 months of age) 3xTg-AD mice will be used.

There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

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Currently, the universal clinical utility of any "conversion" table will be limited by the arguments outlined earlier (ie, differences in individual patient factors, reasons for the switch, etc), and clinicians should appreciate that it is preferable to consider "switch" tables as an important benchmark to identify an estimated starting switch dose that can be implemented safely, with the understanding that additional adjustments should be expected for the circumstances of each patient.

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